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Localization of PKA Phosphorylation Site, Serine-2030, in the Three-Dimensional Structure of Cardiac Ryanodine Receptor

Protein kinase A (PKA)-dependent phosphorylation of the cardiac Ca(2+) release channel/ryanodine receptor (RyR2) is believed to directly dissociate FKBP12.6 from the channel, causing abnormal channel activation and Ca(2+) release. To gain insight into the structural basis of the regulation of RyR2 b...

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Detalhes bibliográficos
Main Authors: Jones, Peter P., Meng, Xing, Xiao, Bailong, Cai, Shitian, Bolstad, Jeff, Wagenknecht, Terence, Liu, Zheng, Chen, S. R. Wayne
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791347/
https://ncbi.nlm.nih.gov/pubmed/17967164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20071257
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