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Conformational Dynamics inside Amino-Terminal Disease Hotspot of Ryanodine Receptor
The N-terminal region of both skeletal and cardiac ryanodine receptor is a disease mutation hotspot. Recently, a crystal structure of the RyR1 fragment (residues 1-559) was solved. This N-terminal structure contains three separate domains, A, B, and C, and was docked into a central vestibule in a fu...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3826818/ https://ncbi.nlm.nih.gov/pubmed/24139989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.09.004 |
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