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Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase
To efficiently catalyze a chemical reaction, enzymes are required to maintain fast rates for formation of the Michaelis complex, the chemical reaction and product release. These distinct demands could be satisfied via fluctuation between different conformational substates (CSs) with unique configura...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2799856/ https://ncbi.nlm.nih.gov/pubmed/19966226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907548106 |
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