A 5000-Fold Increase in the Specificity of a Bacterial Phosphotriesterase for Malathion through Combinatorial Active Site Mutagenesis

Phosphotriesterases (PTEs) have been isolated from a range of bacterial species, including Agrobcaterium radiobacter (PTE(Ar)), and are efficient enzymes with broad substrate ranges. The turnover rate of PTE(Ar) for the common organophosphorous insecticide malathion is lower than expected based on i...

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Autori principali: Naqvi, Tatheer, Warden, Andrew C., French, Nigel, Sugrue, Elena, Carr, Paul D., Jackson, Colin J., Scott, Colin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983157/
https://ncbi.nlm.nih.gov/pubmed/24721933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094177
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