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A 5000-Fold Increase in the Specificity of a Bacterial Phosphotriesterase for Malathion through Combinatorial Active Site Mutagenesis
Phosphotriesterases (PTEs) have been isolated from a range of bacterial species, including Agrobcaterium radiobacter (PTE(Ar)), and are efficient enzymes with broad substrate ranges. The turnover rate of PTE(Ar) for the common organophosphorous insecticide malathion is lower than expected based on i...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3983157/ https://ncbi.nlm.nih.gov/pubmed/24721933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094177 |
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