PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis

FGF21 is a hormone produced in liver and fat that dramatically improves peripheral insulin sensitivity and lipid metabolism. We show here that obese mice with genetically reduced levels of a key hepatic transcriptional coactivator, PGC-1α, have improved whole-body insulin sensitivity with increased...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Estall, Jennifer L., Ruas, Jorge L., Choi, Cheol Soo, Laznik, Dina, Badman, Michael, Maratos-Flier, Eleftheria, Shulman, Gerald I., Spiegelman, Bruce M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799738/
https://ncbi.nlm.nih.gov/pubmed/20018698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912533106
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados