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PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis
FGF21 is a hormone produced in liver and fat that dramatically improves peripheral insulin sensitivity and lipid metabolism. We show here that obese mice with genetically reduced levels of a key hepatic transcriptional coactivator, PGC-1α, have improved whole-body insulin sensitivity with increased...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2799738/ https://ncbi.nlm.nih.gov/pubmed/20018698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912533106 |
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