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Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbα

Intracellular heme levels must be tightly regulated to maintain proper mitochondrial respiration while minimizing toxicity, but the homeostatic mechanisms are not well understood. Here we report a novel negative feedback mechanism whereby the nuclear heme receptor Rev-erbα tightly controls the level...

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Bibliografiske detaljer
Main Authors: Wu, Nan, Yin, Lei, Hanniman, Elyisha A., Joshi, Shree, Lazar, Mitchell A.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2751986/
https://ncbi.nlm.nih.gov/pubmed/19710360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1825809
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