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E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erbα

The metazoan circadian clock mechanism involves cyclic transcriptional activation and repression by proteins whose degradation is highly regulated via the ubiquitin-proteasome pathway. The heme receptor Rev-erbα, a core negative component of the circadian network, controls circadian oscillation of s...

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Hlavní autoři: Yin, Lei, Joshi, Shree, Wu, Nan, Tong, Xin, Lazar, Mitchell A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895127/
https://ncbi.nlm.nih.gov/pubmed/20534529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000438107
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