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E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erbα
The metazoan circadian clock mechanism involves cyclic transcriptional activation and repression by proteins whose degradation is highly regulated via the ubiquitin-proteasome pathway. The heme receptor Rev-erbα, a core negative component of the circadian network, controls circadian oscillation of s...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2895127/ https://ncbi.nlm.nih.gov/pubmed/20534529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000438107 |
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