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Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

Huntington disease (HD) is an inherited neurological disorder caused by a polyglutamine expansion in the protein huntingtin and is characterized by selective neurodegeneration that preferentially occurs in striatal medium spiny neurons. Because the medium spiny neurons are innervated abundantly by g...

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Bibliografiske detaljer
Main Authors: Bradford, Jennifer, Shin, Ji-Yeon, Roberts, Meredith, Wang, Chuan-En, Li, Xiao-Jiang, Li, Shihua
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799722/
https://ncbi.nlm.nih.gov/pubmed/20018729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911503106
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