Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females

Apolipoprotein E (apoE) mediates the redistribution of lipids among cells and is expressed at highest levels in brain and liver. Human apoE exists in three major isoforms encoded by distinct alleles (ɛ(2), ɛ(3), and ɛ(4)). Compared with APOE ɛ(2) and ɛ(3), APOE ɛ(4) increases the risk of cognitive i...

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Bibliographische Detailangaben
Hauptverfasser: Raber, Jacob, Wong, Derek, Buttini, Manuel, Orth, Matthias, Bellosta, Stefano, Pitas, Robert E., Mahley, Robert W., Mucke, Lennart
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 1998
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC27995/
https://ncbi.nlm.nih.gov/pubmed/9724804
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