Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females

Apolipoprotein E (apoE) mediates the redistribution of lipids among cells and is expressed at highest levels in brain and liver. Human apoE exists in three major isoforms encoded by distinct alleles (ɛ(2), ɛ(3), and ɛ(4)). Compared with APOE ɛ(2) and ɛ(3), APOE ɛ(4) increases the risk of cognitive i...

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Autores principales: Raber, Jacob, Wong, Derek, Buttini, Manuel, Orth, Matthias, Bellosta, Stefano, Pitas, Robert E., Mahley, Robert W., Mucke, Lennart
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 1998
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC27995/
https://ncbi.nlm.nih.gov/pubmed/9724804
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