Apolipoprotein E – Low Density Lipoprotein Receptor Interaction Affects Spatial Memory Retention and Brain ApoE Levels in an Isoform-Dependent Manner

Human apolipoprotein E (apoE) exists in three isoforms: apoE2, apoE3 and apoE4. APOE ε4 (E4) is a major genetic risk factor for cardiovascular disease (CVD) and Alzheimer's disease (AD). ApoE mediates cholesterol metabolism by binding various receptors. The low-density lipoprotein receptor (LDL...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Johnson, Lance A., Olsen, Reid H.J., Merkens, Louise S., DeBarber, Andrea, Steiner, Robert D., Sullivan, Patrick M., Maeda, Nobuyo, Raber, Jacob
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936477/
https://ncbi.nlm.nih.gov/pubmed/24412220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2013.12.016
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