Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice.

apoE deficiency causes hyperlipidemia and premature atherosclerosis. To determine if macrophage-specific expression of apoE would decrease the extent of atherosclerosis, we expressed human apoE in macrophages of apoE-null mice (apoE-/-) and assessed the effect on lipid accumulation in cells of the a...

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Detalhes bibliográficos
Main Authors: Bellosta, S, Mahley, R W, Sanan, D A, Murata, J, Newland, D L, Taylor, J M, Pitas, R E
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC185866/
https://ncbi.nlm.nih.gov/pubmed/7593602
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