Interactions between Lipids and Human Anti-HIV Antibody 4E10 Can Be Reduced without Ablating Neutralizing Activity

Human 4E10 is one of the broadest-specificity, HIV-1-neutralizing monoclonal antibodies known, recognizing a membrane-proximal linear epitope on gp41. The lipid cross-reactivity of 4E10 has been alternately suggested either to contribute to the apparent rarity of 4E10-like antibody responses in HIV...

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Main Authors: Xu, Hengyu, Song, Likai, Kim, Mikyung, Holmes, Margaret A., Kraft, Zane, Sellhorn, George, Reinherz, Ellis L., Stamatatos, Leonidas, Strong, Roland K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798360/
https://ncbi.nlm.nih.gov/pubmed/19906921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02113-09
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