Engineering, Expression, Purification, and Characterization of Stable Clade A/B Recombinant Soluble Heterotrimeric gp140 Proteins

The envelope glycoprotein (Env) of human immunodeficiency virus type 1 (HIV-1) is composed of two noncovalently associated subunits: an extracellular subunit (gp120) and a transmembrane subunit (gp41). The functional unit of Env on the surface of infectious virions is a trimer of gp120/gp41 heterodi...

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Detalhes bibliográficos
Main Authors: Sellhorn, George, Kraft, Zane, Caldwell, Zachary, Ellingson, Katharine, Mineart, Christine, Seaman, Michael S., Montefiori, David C., Lagerquist, Eliza, Stamatatos, Leonidas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255899/
https://ncbi.nlm.nih.gov/pubmed/22031951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06363-11
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