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Functional Cooperation of the Proapoptotic Bcl2 Family Proteins Bmf and Bim In Vivo

Bcl2-modifying factor (Bmf) is a member of the BH3-only group of proapoptotic proteins. To test the role of Bmf in vivo, we constructed mice with a series of mutated Bmf alleles that disrupt Bmf expression, prevent Bmf phosphorylation by the c-Jun NH(2)-terminal kinase (JNK) on Ser(74), or mimic Bmf...

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Detalhes bibliográficos
Main Authors: Hübner, Anette, Cavanagh-Kyros, Julie, Rincon, Mercedes, Flavell, Richard A., Davis, Roger J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798311/
https://ncbi.nlm.nih.gov/pubmed/19841067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01155-09
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