Proapoptotic Bcl-2 Family Member Bim Promotes Persistent Infection and Limits Protective Immunity

Following the peak of the T-cell response, most of the activated effector T cells die by apoptosis driven by the proapoptotic Bcl-2 family member Bim (Bcl-2-interacting mediator of death). Whether the absence of Bim-mediated T-cell apoptosis can affect protective immunity remains unclear. Here, we u...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Reckling, Stacie, Divanovic, Senad, Karp, Christopher L., Wojciechowski, Sara, Belkaid, Yasmine, Hildeman, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Fungal and Parasitic Infections
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258821/
https://ncbi.nlm.nih.gov/pubmed/18086806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01093-06
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