A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in Apc(Min)/+ mice

Previous studies of Min/+ (multiple intestinal neoplasia) mice on a sensitive genetic background, C57BL/6 (B6), showed that adenomas have lost heterozygosity for the germ-line Apc(Min) mutation in the Apc (adenomatous polyposis coli) gene. We now report that on a strongly resistant genetic backgroun...

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Autores principales: Shoemaker, Alex R., Moser, Amy R., Midgley, Carol A., Clipson, Linda, Newton, Michael A., Dove, William F.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 1998
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC27980/
https://ncbi.nlm.nih.gov/pubmed/9724789
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