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A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in Apc(Min)/+ mice
Previous studies of Min/+ (multiple intestinal neoplasia) mice on a sensitive genetic background, C57BL/6 (B6), showed that adenomas have lost heterozygosity for the germ-line Apc(Min) mutation in the Apc (adenomatous polyposis coli) gene. We now report that on a strongly resistant genetic backgroun...
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| Glavni autori: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The National Academy of Sciences
1998
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC27980/ https://ncbi.nlm.nih.gov/pubmed/9724789 |
| Oznake: |
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