Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice

Abstract Cytosolic Malic Enzyme (ME1) provides reduced NADP for anabolism and maintenance of redox status. To examine the role of ME1 in tumor genesis of the gastrointestinal tract, we crossed mice having augmented intestinal epithelial expression of ME1 (ME1-Tg mice) with ApcMin/+ mice to obtain ma...

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主要な著者:	Lorenzo M. Fernandes, Ahmed Al-Dwairi, Rosalia C. M. Simmen, Meera Marji, Dustin M. Brown, Sarah W. Jewell, Frank A. Simmen
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2018-09-01
シリーズ:	Scientific Reports
主題:	Apc Min Male ApcMin Crypt Depth Villus Length Villus Lamina Propria
オンライン･アクセス:	https://doi.org/10.1038/s41598-018-32532-w
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