Dysfunctional mucus structure in cystic fibrosis increases vulnerability to colibactin-mediated DNA adducts in the colon mucosa

Colibactin is a recently characterized pro-carcinogenic genotoxin produced by pks+ Escherichia coli. We hypothesized that cystic fibrosis (CF)-associated dysfunctional mucus structure increases the vulnerability of host mucosa to colibactin-induced DNA damage. In this pilot study, we tested healthy-...

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Auteurs principaux:	Amanda Mandarino Alves, Chiara Lecchi, Sharon Lopez, Alessia Stornetta, Prince P. Mathai, Peter W. Villalta, Satoshi Ishii, Emily P. Balskus, Silvia Balbo, Alexander Khoruts
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis Group 2024-12-01
Collection:	Gut Microbes
Sujets:	cystic fibrosis colon cancer colibactin pks+ E. coli microbiota
Accès en ligne:	https://www.tandfonline.com/doi/10.1080/19490976.2024.2387877
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