Disruption of estrogen receptor signaling enhances intestinal neoplasia in Apc(Min/+) mice

Estrogen receptors (ERs) [ERα (Esr1) and ERβ (Esr2)] are expressed in the human colon, but during the multistep process of colorectal carcinogenesis, expression of both ERα and ERβ is lost, suggesting that loss of ER function might promote colorectal carcinogenesis. Through crosses between an ERα kn...

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Autori principali: Cleveland, Alicia G., Oikarinen, Seija I., Bynoté, Kimberly K., Marttinen, Maija, Rafter, Joseph J., Gustafsson, Jan-Åke, Roy, Shyamal K., Pitot, Henry C., Korach, Kenneth S., Lubahn, Dennis B., Mutanen, Marja, Gould, Karen A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2009
Soggetti:
Carcinogenesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736300/
https://ncbi.nlm.nih.gov/pubmed/19520794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgp132
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