Muscarinic receptor subtype-3 gene ablation and scopolamine butylbromide treatment attenuate small intestinal neoplasia in Apc(min/+) mice

M3 subtype muscarinic receptors (CHRM3) are over-expressed in colon cancer. In this study, we used Apc(min/+) mice to identify the role of Chrm3 expression in a genetic model of intestinal neoplasia, explored the role of Chrm3 in intestinal mucosal development and determined the translational potent...

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Bibliografske podrobnosti
Main Authors: Raufman, Jean-Pierre, Shant, Jasleen, Xie, Guofeng, Cheng, Kunrong, Gao, Xue-Min, Shiu, Brian, Shah, Nirish, Drachenberg, Cinthia B., Heath, Jonathon, Wess, Jürgen, Khurana, Sandeep
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
Carcinogenesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165126/
https://ncbi.nlm.nih.gov/pubmed/21705482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr118
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