Divergent effects of muscarinic receptor subtype gene ablation on murine colon tumorigenesis reveals association of M3R and zinc finger protein 277 expression in colon neoplasia

BACKGROUND: M3 and M1 subtype muscarinic receptors are co-expressed in normal and neoplastic intestinal epithelial cells. In mice, ablating Chrm3, the gene encoding M3R, robustly attenuates intestinal tumor formation. Here we investigated the effects of Chrm1 gene ablation, alone and in combination...

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Библиографические подробности
Главные авторы: Cheng, Kunrong, Xie, Guofeng, Khurana, Sandeep, Heath, Jonathon, Drachenberg, Cinthia B, Timmons, Jennifer, Shah, Nirish, Raufman, Jean-Pierre
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2014
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Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021221/
https://ncbi.nlm.nih.gov/pubmed/24694019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-77
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