Divergent effects of muscarinic receptor subtype gene ablation on murine colon tumorigenesis reveals association of M3R and zinc finger protein 277 expression in colon neoplasia

BACKGROUND: M3 and M1 subtype muscarinic receptors are co-expressed in normal and neoplastic intestinal epithelial cells. In mice, ablating Chrm3, the gene encoding M3R, robustly attenuates intestinal tumor formation. Here we investigated the effects of Chrm1 gene ablation, alone and in combination...

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Autores principales: Cheng, Kunrong, Xie, Guofeng, Khurana, Sandeep, Heath, Jonathon, Drachenberg, Cinthia B, Timmons, Jennifer, Shah, Nirish, Raufman, Jean-Pierre
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021221/
https://ncbi.nlm.nih.gov/pubmed/24694019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-77
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