Divergent effects of muscarinic receptor subtype gene ablation on murine colon tumorigenesis reveals association of M3R and zinc finger protein 277 expression in colon neoplasia

BACKGROUND: M3 and M1 subtype muscarinic receptors are co-expressed in normal and neoplastic intestinal epithelial cells. In mice, ablating Chrm3, the gene encoding M3R, robustly attenuates intestinal tumor formation. Here we investigated the effects of Chrm1 gene ablation, alone and in combination...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Cheng, Kunrong, Xie, Guofeng, Khurana, Sandeep, Heath, Jonathon, Drachenberg, Cinthia B, Timmons, Jennifer, Shah, Nirish, Raufman, Jean-Pierre
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2014
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021221/
https://ncbi.nlm.nih.gov/pubmed/24694019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-77
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