Dvl2 promotes intestinal length and neoplasia in the Apc(Min) mouse model for colorectal cancer

APC mutations cause activation of Wnt/β-catenin signalling, which invariably leads to colorectal cancer. Similarly, overexpressed Dvl proteins are potent activators of β-catenin signalling. Screening a large tissue microarray of different staged colorectal tumours by immunohistochemistry, we found t...

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Hlavní autoři: Metcalfe, Ciara, Ibrahim, Ashraf E. K., Graeb, Michael, de la Roche, Marc, Schwarz-Romond, Thomas, Fiedler, Marc, Winton, Douglas J., Corfield, Anthony, Bienz, Mariann
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923074/
https://ncbi.nlm.nih.gov/pubmed/20663899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1616
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