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Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models
Bcl9 and Pygo are Wnt enhanceosome components that effect β-catenin-dependent transcription. Whether they mediate β-catenin-dependent neoplasia is unclear. Here we assess their roles in intestinal tumourigenesis initiated by Apc loss-of-function (Apc(Min)), or by Apc(1322T) encoding a partially-func...
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| Veröffentlicht in: | Nat Commun |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6374407/ https://ncbi.nlm.nih.gov/pubmed/30760710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08164-z |
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