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Dvl2 promotes intestinal length and neoplasia in the Apc(Min) mouse model for colorectal cancer
APC mutations cause activation of Wnt/β-catenin signalling, which invariably leads to colorectal cancer. Similarly, overexpressed Dvl proteins are potent activators of β-catenin signalling. Screening a large tissue microarray of different staged colorectal tumours by immunohistochemistry, we found t...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2923074/ https://ncbi.nlm.nih.gov/pubmed/20663899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1616 |
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