Co-Inhibition of BCL-W and BCL2 Restores Antiestrogen Sensitivity through BECN1 and Promotes an Autophagy-Associated Necrosis

BCL2 family members affect cell fate decisions in breast cancer but the role of BCL-W (BCL2L2) is unknown. We now show the integrated roles of the antiapoptotic BCL-W and BCL2 in affecting responsiveness to the antiestrogen ICI 182,780 (ICI; Fulvestrant Faslodex), using both molecular (siRNA; shRNA)...

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Detalhes bibliográficos
Main Authors: Crawford, Anatasha C., Riggins, Rebecca B., Shajahan, Ayesha N., Zwart, Alan, Clarke, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797635/
https://ncbi.nlm.nih.gov/pubmed/20062536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008604
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