BCL2 and CASP8 regulation by NF-κB differentially affect mitochondrial function and cell fate in antiestrogen-sensitive and -resistant breast cancer cells

Resistance to endocrine therapies remains a major problem in the management of estrogen receptor-α (ER)-positive breast cancer. We show that inhibition of NF-κB (p65/RELA), either by overexpression of a mutant IκB (IκBSR) or a small-molecule inhibitor of NF-κB (parthenolide; IC(50)=500 nM in tamoxif...

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Detalhes bibliográficos
Main Authors: Nehra, Ruchi, Riggins, Rebecca B., Shajahan, Ayesha N., Zwart, Alan, Crawford, Anatasha C., Clarke, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2010
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874480/
https://ncbi.nlm.nih.gov/pubmed/20154269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-138305
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