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Interferon Gamma Restores Breast Cancer Sensitivity to Fulvestrant by Regulating STAT1, IRF1, NFκB, BCL2 Family Members, and Signaling to Caspase-dependent Apoptosis

Antiestrogens are effective therapies for the management of many estrogen receptor-alpha positive (ER+) breast cancers. Nonetheless, both de novo and acquired resistance occur and remain major problems in the clinical setting. Interferon gamma (IFNγ) is an inflammatory cytokine that induces the expr...

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Detalhes bibliográficos
Main Authors: Ning, Yanxia, Riggins, Rebecca B., Mulla, Jennifer E., Chung, Haniee, Zwart, Alan, Clarke, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925293/
https://ncbi.nlm.nih.gov/pubmed/20457620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-1169
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