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Interferon Gamma Restores Breast Cancer Sensitivity to Fulvestrant by Regulating STAT1, IRF1, NFκB, BCL2 Family Members, and Signaling to Caspase-dependent Apoptosis
Antiestrogens are effective therapies for the management of many estrogen receptor-alpha positive (ER+) breast cancers. Nonetheless, both de novo and acquired resistance occur and remain major problems in the clinical setting. Interferon gamma (IFNγ) is an inflammatory cytokine that induces the expr...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2925293/ https://ncbi.nlm.nih.gov/pubmed/20457620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-1169 |
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