Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

The Bcl-2 family of proteins regulates apoptosis, the cell death program triggered by activation of certain proteases (caspases). An attractive model for how Bcl-2 and its closest relatives prevent caspase activation is that they bind to and inactivate an adaptor protein required for procaspase proc...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Moriishi, Kohji, Huang, David C. S., Cory, Suzanne, Adams, Jerry M.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1999
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22270/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10449754/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.17.9683
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