Activating Mutations of the TRPML1 Channel Revealed by Proline-scanning Mutagenesis

The mucolipin TRP (TRPML) proteins are a family of endolysosomal cation channels with genetically established importance in humans and rodent. Mutations of human TRPML1 cause type IV mucolipidosis, a devastating pediatric neurodegenerative disease. Our recent electrophysiological studies revealed th...

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Bibliographic Details
Main Authors: Dong, Xian-ping, Wang, Xiang, Shen, Dongbiao, Chen, Su, Liu, Meiling, Wang, Yanbin, Mills, Eric, Cheng, Xiping, Delling, Markus, Xu, Haoxing
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Membrane Transport, Structure, Function, and Biogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797275/
https://ncbi.nlm.nih.gov/pubmed/19638346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.037184
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