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Structure-Function Studies of Claudin Extracellular Domains by Cysteine-scanning Mutagenesis
Claudins form size- and charge-selective pores in the tight junction that control the paracellular flux of inorganic ions and small molecules. However, the structural basis for ion selectivity of paracellular pores is poorly understood. Here we applied cysteine scanning to map the paracellular pathw...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2781464/ https://ncbi.nlm.nih.gov/pubmed/19690347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.043752 |
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