Structure-Function Studies of Claudin Extracellular Domains by Cysteine-scanning Mutagenesis

Claudins form size- and charge-selective pores in the tight junction that control the paracellular flux of inorganic ions and small molecules. However, the structural basis for ion selectivity of paracellular pores is poorly understood. Here we applied cysteine scanning to map the paracellular pathw...

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Bibliographic Details
Main Authors: Angelow, Susanne, Yu, Alan S. L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Membrane Transport, Structure, Function, and Biogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781464/
https://ncbi.nlm.nih.gov/pubmed/19690347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.043752
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