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Structural Elements for the Generation of Sustained Currents by the Acid Pain Sensor ASIC3

ASIC3 is an acid-sensing ion channel expressed in sensory neurons, where it participates in acidic and inflammatory pain. In addition to the “classical” transient current, ASIC3 generates a sustained current essential for pain perception. Using chimeras between the ASIC3 and ASIC1a channels we show...

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Detalhes bibliográficos
Main Authors: Salinas, Miguel, Lazdunski, Michel, Lingueglia, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797256/
https://ncbi.nlm.nih.gov/pubmed/19778905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.043984
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