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Identification of Protein Domains That Control Proton and Calcium Sensitivity of ASIC1a
The acid-sensing ion channels (ASICs) open in response to extracellular acidic pH, and individual subunits display differential sensitivity to protons and calcium. ASIC1a acts as a high affinity proton sensor, whereas ASIC2a requires substantially greater proton concentrations to activate. Using chi...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2788841/ https://ncbi.nlm.nih.gov/pubmed/19654327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.029009 |
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