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Two residues in the extracellular domain convert a nonfunctional ASIC1 into a proton-activated channel
Acid-sensing ion channels (ASICs) are proton-activated sodium channels of the nervous system. Mammals express four ASICs, and orthologs of these genes have been found in all chordates examined to date. Despite a high degree of sequence conservation of all ASICs across species, the response to a give...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3774166/ https://ncbi.nlm.nih.gov/pubmed/20427715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00100.2010 |
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