Two residues in the extracellular domain convert a nonfunctional ASIC1 into a proton-activated channel

Acid-sensing ion channels (ASICs) are proton-activated sodium channels of the nervous system. Mammals express four ASICs, and orthologs of these genes have been found in all chordates examined to date. Despite a high degree of sequence conservation of all ASICs across species, the response to a give...

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Bibliographic Details
Main Authors: Li, Tianbo, Yang, Youshan, Canessa, Cecilia M.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2010
Subjects:
Membrane Transporters, Ion Channels and Pumps
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774166/
https://ncbi.nlm.nih.gov/pubmed/20427715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00100.2010
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