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Leu(85) in the β1-β2 Linker of ASIC1 Slows Activation and Decreases the Apparent Proton Affinity by Stabilizing a Closed Conformation

Acid-sensing ion channels (ASICs) are proton-activated channels expressed in neurons of the central and peripheral nervous systems where they modulate neuronal activity in response to external increases in proton concentration. The size of ASIC1 currents evoked by a given local acidification is dete...

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Detalhes bibliográficos
Main Authors: Li, Tianbo, Yang, Youshan, Canessa, Cecilia M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903392/
https://ncbi.nlm.nih.gov/pubmed/20479002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.134114
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