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Asn(415) in the β11-β12 Linker Decreases Proton-dependent Desensitization of ASIC1
Neurons of the mammalian nervous system express the proton-sensing ion channel ASIC1. Low concentrations of protons in the normal range of extracellular pH, pH 7.4–7.3, shut the pore by a conformational transition referred as steady-state desensitization. Therefore, the potential of local acidificat...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2951203/ https://ncbi.nlm.nih.gov/pubmed/20675379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.160382 |
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