Differential regulation of HIF-1α isoforms in murine macrophages by TLR4 and adenosine A(2A) receptor agonists

Adenosine A(2A)R and TLR agonists synergize to induce an “angiogenic switch” in macrophages, down-regulating TNF-α and up-regulating VEGF expression. This switch involves transcriptional regulation of VEGF by HIF-1, transcriptional induction of HIF-1α by LPS (TLR4 agonist), and A(2A)R-dependent post...

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Bibliografski detalji
Glavni autori: Ramanathan, Madhuri, Luo, Wenting, Csóka, Balázs, Haskó, György, Lukashev, Dmitry, Sitkovsky, Michail V., Leibovich, Samuel Joseph
Format: Artigo
Jezik:Inglês
Izdano: The Society for Leukocyte Biology 2009
Teme:
Receptors, Signal Transduction, & Genes
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796622/
https://ncbi.nlm.nih.gov/pubmed/19477908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0109021
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