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Genetic deletion of the alternative isoform I.1 of HIF-1α in T cells enhances anti-bacterial immune response and improves survival in the model of bacterial peritonitis in mice
Hypoxia-adenosinergic suppression and re-direction of the immune response has been implicated in the regulation of anti-pathogen and anti-tumor immunity, with Hypoxia-inducible factor 1α (HIF-1α) playing a major role. In this study, we investigated the role of isoform I.1, a quantitatively minor alt...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3757952/ https://ncbi.nlm.nih.gov/pubmed/23208786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201242765 |
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