A2B Adenosine Receptor Blockade Enhances Macrophage-Mediated Bacterial Phagocytosis and Improves Polymicrobial Sepsis Survival in Mice

Antimicrobial treatment strategies must improve to reduce the high mortality rates in septic patients. In noninfectious models of acute inflammation, activation of A2B adenosine receptors (A2BR) in extracellular adenosine-rich microenvironments causes immunosuppression. We examined A2BR in antibacte...

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Bibliographic Details
Main Authors: Belikoff, Bryan G., Hatfield, Stephen, Georgiev, Peter, Ohta, Akio, Lukashev, Dmitriy, Buras, Jon A., Remick, Daniel G., Sitkovsky, Michail
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708265/
https://ncbi.nlm.nih.gov/pubmed/21242513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001567
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