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Differential regulation of HIF-1α isoforms in murine macrophages by TLR4 and adenosine A(2A) receptor agonists
Adenosine A(2A)R and TLR agonists synergize to induce an “angiogenic switch” in macrophages, down-regulating TNF-α and up-regulating VEGF expression. This switch involves transcriptional regulation of VEGF by HIF-1, transcriptional induction of HIF-1α by LPS (TLR4 agonist), and A(2A)R-dependent post...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Society for Leukocyte Biology
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2796622/ https://ncbi.nlm.nih.gov/pubmed/19477908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0109021 |
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