Amyloid precursor protein increases cortical neuron size in transgenic mice

The amyloid precursor protein (APP) is the source of β-amyloid, a pivotal peptide in the pathogenesis of Alzheimer’s disease (AD). This study examines the possible effect of APP transgene expression on neuronal size by measuring the volumes of cortical neurons (μm(3)) in transgenic mouse models with...

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Bibliographische Detailangaben
Hauptverfasser: Oh, Esther S., Savonenko, Alena V., King, Julie F., Fangmark Tucker, Stina M., Rudow, Gay L., Xu, Guilian, Borchelt, David R., Troncoso, Juan C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796369/
https://ncbi.nlm.nih.gov/pubmed/18304698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2007.12.024
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