Amyloid precursor protein increases cortical neuron size in transgenic mice

The amyloid precursor protein (APP) is the source of β-amyloid, a pivotal peptide in the pathogenesis of Alzheimer’s disease (AD). This study examines the possible effect of APP transgene expression on neuronal size by measuring the volumes of cortical neurons (μm(3)) in transgenic mouse models with...

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Bibliographic Details
Main Authors: Oh, Esther S., Savonenko, Alena V., King, Julie F., Fangmark Tucker, Stina M., Rudow, Gay L., Xu, Guilian, Borchelt, David R., Troncoso, Juan C.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796369/
https://ncbi.nlm.nih.gov/pubmed/18304698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2007.12.024
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