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Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase
The Cul3-based E3 ubiquitin ligases regulate many cellular processes using a large family of BTB domain–containing proteins as their target recognition components, but how they recognize targets remains unknown. Here we identify and characterize degrons that mediate the degradation of the Hedgehog p...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2795488/ https://ncbi.nlm.nih.gov/pubmed/19955409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912008106 |
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