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Stability of HIB-Cul3 E3 ligase adaptor HIB Is Regulated by Self-degradation and Availability of Its Substrates

The HIB-Cul3 complex E3 ligase regulates physiological homeostasis through regulating its substrate stability and its activity can be modulated by changing HIB abundance. However, regulation of HIB remains elusive. Here we provide evidence that HIB is degraded through the proteasome by Cul3-mediated...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Zhou, Zizhang, Xu, Congyu, Chen, Ping, Liu, Chen, Pang, Shu, Yao, Xia, Zhang, Qing
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533009/
https://ncbi.nlm.nih.gov/pubmed/26263855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12709
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