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Resistance to Arginine Deiminase Treatment in Melanoma Cells Is Associated with Induced Argininosuccinate Synthetase Expression involving c-Myc/HIF-1α/Sp4

Arginine deiminase (ADI)-based arginine depletion is a novel strategy under clinical trials for the treatment of malignant melanoma with promising results. The sensitivity of melanoma to ADI treatment is based on its auxotrophy for arginine due to a lack of argininosuccinate synthetase (AS) expressi...

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Bibliografiske detaljer
Main Authors: Tsai, Wen-Bin, Aiba, Isamu, Lee, Soo-yong, Feun, Lynn, Savaraj, Niramol, Kuo, Macus Tien
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795119/
https://ncbi.nlm.nih.gov/pubmed/19934275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0794
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